Navigators are available Monday through Friday from am to pm ET. Or, start your online profile with Step 1 listed near the bottom of the page. A list of clinical trials will appear if your search criteria has found a match or multiple matches. This will help to eliminate the trials that are not currently recruiting. Scroll through and click on the trials listed. Each trial will have a name, clinical trial ID number, purpose statement, eligibility criteria, contact information, and locations.
For more selective search options, you can include what type of trial you are looking for i. Each trial wi ll have a name, current phase i. Enter your search criteria, such as tumor type, treatment type, trial phase, age group, country, etc. A list of clinical trials will appear with the treatment or trial name, location, and the date it was last updated on the website.
The treatment name, phase, age group, tumor type, trial information, contact information, and locations will appear. A Catalyst Moment It is a pivotal moment for our world, our nation, and our brain tumor community.
The purpose of this study is to evaluate the side effects and best dose of nivolumab when given together with multi-fraction stereotactic radiosurgery and to see how well they work with or without ipilimumab in treating participants with grade II-III meningioma that has come back.
Monoclonal antibodies, such as nivolumab and ipilimumab, may interfere with the ability of tumor cells to grow and spread. Stereotactic radiosurgery is a specialized radiation therapy that delivers a single, high dose of radiation directly to the tumor and may cause less damage to normal tissue. It is not yet known whether giving nivolumab and multi-fraction The goal of this study is to correlate protein content in vestibular schwannomas and cerebrospinal fluid to patient outcomes, imaging findings, and other relevant clinical endpoints in patients who presented with both this tumor type and hydrocephalus.
This phase II trial studies how well dynamic susceptibility contrast-enhanced magnetic resonance imaging DSC-MRI works in measuring relative cerebral blood volume rCBV for early response to bevacizumab in patients with glioblastoma that has come back. Recent studies using chemotherapy and radiation therapy have been shown to be effective in treating patients with WNT-driven medulloblastoma.
However, there is a concern about the late side effects of treatment, such as learning difficulties, lower amounts of hormones, or other problems in performing daily activities. Radiotherapy uses high-energy radiation from x-rays to kill cancer cells and shrink tumors.
Drugs used in chemotherapy, such as This randomized phase III trial is studying two different combination chemotherapy regimens to compare how well they work when given before a peripheral stem cell transplant in treating young patients with newly diagnosed supratentorial primitive neuroectodermal tumors or high-risk medulloblastoma.
Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug combination chemotherapy together with a peripheral stem cell transplant may allow more chemotherapy to be given so that more tumor cells are killed.
It is not yet known which This randomized phase II trial studies how well low-dose lenalidomide works compared with high-dose lenalidomide in treating children with juvenile pilocytic astrocytomas or optic nerve pathway gliomas that have come back recurrent , have not responded to treatment refractory , or are growing, spreading, or getting worse progressive. Lenalidomide may stop the growth of tumor cells by blocking blood flow to the tumor. It is not yet known whether low-dose lenalidomide is more or less effective than high-dose lenalidomide in treating patients with juvenile pilocytic astrocytomas or optic nerve pathway gliomas.
The purpose of this study is to evaluate the feasibility of twice daily memantine started before radiation therapy RT and continued one month after radiation therapy RT , and to evaluate the feasibility of twice daily BID memantine started before RT and continued 3 and 6 months after RT.
The purpose of this study is to compare the effectiveness of AG to placebo in participants with residual or recurrent Grade 2 glioma with an IDH1 or IDH2 mutation who have undergone surgery as their only treatment.
Participants will be required to have central confirmation of IDH mutation status prior to randomization. Selumetinib is a drug that works by blocking some enzymes that low grade glioma tumor cells need for their growth. This results in killing tumor cells. Drugs used as chemotherapy, such as carboplatin and vincristine, work in different ways to stop the growth of tumor cells, either by This randomized phase II trial studies how well giving temozolomide and irinotecan hydrochloride together with or without bevacizumab works in treating young patients with recurrent or refractory medulloblastoma or central nervous system CNS primitive neuroectodermal tumors.
Drugs used in chemotherapy, such as temozolomide and irinotecan hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Others find tumor cells Cohort 1 includes blood collections for in vitro studies which are a component of NIH-funded Project 3 within the Mayo Clinic The purpose of this research study is to understand the natural history of vision in patients with OPG and determine if there are factors e.
Another purpose of the study is to collect and store blood and tissue samples to use for future research to evaluate if there are certain variations in DNA, RNA, or proteins that predict the likelihood of an OPG to grow or cause vision loss. This randomized phase IIb trial studies how well low-dose carvedilol works in preventing heart failure in cancer survivors exposed to high dose anthracyclines for management of childhood cancer.
Patients who received high-dose anthracycline chemotherapy are at a much greater risk for developing heart failure compared to survivors who didn't get any anthracycline chemotherapy. Heart failure happens when the heart muscle has been weakened and can't pump blood as well as it should. Carvedilol may help lower the risk of cardiovascular complications.
The study aims to characterize patient factors, such as pre-existing comorbidities, cancer type and treatment, and demographic factors, associated with short- and long-term outcomes of COVID, including severity and fatality, in cancer patients undergoing treatment. The study also is aimed to describe cancer treatment modifications made in response to COVID, including dose adjustments, changes in symptom management, or temporary or permanent cessation. Lastely, evaluate the association of COVID with cancer outcomes in patient subgroups defined by clinico-pathologic characteristics.
The purpose of this study is to evaluate brigatinib alone for patients with brain metastases from anaplastic lymphoma kinase ALK positive non-small cell lung cancer NSCLC , who have either not been treated previously with a tyrosine kinase inhibitor TKI targeting ALK or who have had prior exposure to crizotinib.
The purpose of this study is to assess the safety and effectiveness of combined Toca and Toca FC, versus a standard of care single agent chemotherapy, for patients who are having surgery to remove a first or second recurrence of glioblastoma or anaplastic astrocytoma. Regimen A of this study has been completed and Mayo Clinic will only be participating in the Regimen B portion.
The purpose of this study is assess the pharmacokinetics PK , pharmacodynamics PD and Central Nervous System CNS penetration of CC following short-term interval therapy 4 daily doses prior to surgery, in subjects with progressive or recurrent WHO Grade II Diffuse Astrocytoma, Grade III Anaplastic Astrocytoma and recurrent Glioblastoma who have failed radiation and chemotherapy, and who are candidates for surgical tumor resection as part of their salvage regimen planned salvage resection.
Others find tumor cells and help kill them or carry tumor-killing substances to them. Bevacizumab may also block the growth of the tumor by blocking blood flow to the tumor. It is not yet known whether bevacizumab together with dasatinib are more effective than a placebo in treating patients with recurrent or progressive high-grade glioma or glioblastoma multiforme.
This randomized phase II study aims to investigate whether the addition of bevacizumab to standard corticosteroid therapy results in greater improvement in symptoms and less treatment-induced symptoms compared with standard corticosteroid therapy for patients with symptomatic brain radionecrosis following radiosurgery. It is hypothesized that the addition of bevacizumab to standard care corticosteroids will reduce treatment-induced toxicities and improve neurologic impairments in patients with brain radionecrosis following radiosurgery for brain metastases.
The purpose of this study is to assess the side effects and best dose of ATR kinase inhibitor VX when given together with whole brain radiation therapy for the treatment of patients who have non-small cell lung cancer that has spread from the original primary tumor to the brain. VX may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving VX together with radiation therapy may be a better treatment for non-small cell lung cancer.
Genetic tests look at the unique genetic material genes of patients' tumor cells. Patients with genetic changes or abnormalities mutations may benefit more from treatment which targets their tumor's particular genetic mutation, and may help doctors plan better treatment for This clinical trial is studying long-term follow-up in patients who are or have participated in Children's Oncology Group studies. Developing a way to track patients enrolled in Children's Oncology Group studies will help doctors gather long-term follow-up information and may help the study of cancer in the future.
The device is an experimental, portable, battery operated device for chronic administration of alternating electric fields termed TTFields or TTF to the region of the malignant tumor, by means of surface, insulated electrode arrays. This phase I trial studies the side effects and the best dose of wild-type reovirus viral therapy when given with sargramostim in treating younger patients with high grade brain tumors that have come back or that have not responded to standard therapy.
A virus, called wild-type reovirus, which has been changed in a certain way, may be able to kill tumor cells without damaging normal cells. Sargramostim may increase the production of blood cells and may promote the tumor cell killing effects of wild-type reovirus.
Giving wild-type reovirus together with sargramostim may kill more tumor cells. This study proposes to develop and maintain a biorepository of blood samples collected from patients receiving definitive chemoradiotherapy for locally advanced rectal cancer, locally advanced pancreatic cancer, non-small cell lung cancer, or cervical cancer. The ultimate goal of this biorepository will be to provide the resource to initiate an exploration of ctDNA as a potential liquid biopsy for GI and Thoracic malignancy detection and surveillance.
The purpose of this is to evaluate the safety, effectivess, pharmacokinetics, and pharmacodynamics of FT as a single agent and in combination with other anti-cancer drugs in patients with advanced solid tumors and gliomas. The study is divided into two parts: single agent FT followed by combination therapy.
Part 1: A single agent, open-label study in up to five cohorts glioma, hepatobiliary tumors, chondrosarcoma, intrahepatic cholangiocarcinoma, and other IDH1 mutant solid tumors that will include a Phase 1 dose confirmation followed by a Phase 2 investigation of clinical activity in up to 4 cohorts. During the dose confirmation, additional doses or The purpose of this study is to evaluate the safety and feasibility of intraoperative microdialysis during surgical procedures for central nervous system malignancies.
The purpose of this study is to find out more about the side effects of rovalpituzumab tesirine SC16LD6. THe purpose of this study is to examine the current and potential future therapeutic relevance of pharmacogenomics PGx testing for a cohort of cancer patients in order to improve quality of life QOL in patients receiving clinical care at Mayo Clinic.
The purpose of this study is to develop a biorepository of blood samples from cancer patients participating in the Gemini IRB protocol. These samples will be used for future biomarker discovery and other translational studies. The goal of the study is to create a database of clinical information and a repository of biological specimens for genetic, molecular and microbiological research to better understand hereditary cancer and help develop new therapies and preventive strategies. The purpose of this study is to determine the prevalence of genetic mutations in cancer patients from various ethnic populations seeking care at Mayo Clinic Arizona cancer clinics.
The purpose of this study is to evaluate the challenges, behavioral patterns, and preferences of minority patient participation in clinical trials.
Also, to develop and validate a personalized clinical trial educational platform to boost participation among underserved cancer patients. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below.
Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not endorse any of the third party products and services advertised. A single copy of these materials may be reprinted for noncommercial personal use only. Overview Lung cancer is a very challenging condition to manage, especially when discovered late.
The incredibly high incidence of lung cancer — mostly caused by. Overview The spread of cancer cells beyond the original site of the tumor is a very challenging process. When cancer cells of the breast are. Overview Ever since their discovery, advanced cases of cholangiocarcinoma and gallbladder cancers have been a big issue for doctors to manage.
Since these cancers only. Overview Over the past few years, researchers have been trying to find new treatment protocols for colorectal cancer by combining anticancer drugs. Fortunately, these efforts. Overview Nasopharyngeal carcinoma is a malignant tumor that affects the head and neck. Typically, this cancer starts in the upper part of the throat and.
Overview Melanoma is a unique type of skin cancer that originates from cells known as melanocytes. The main function of these cells is to produce. To check if our service suits your case We need to talk. Improve therapeutic outcomes, prolong life and quality of life , is our main business. Advanced cases of cervical cancer pose a challenge for physicians to treat. Once the cancer cells have spread to other tissues, procedures such as surgery and curative radiation therapy become less effective.
Fortunately, we still have chemotherapy and immunotherapy. Both of which are switching to combination treatments that show promising results. In this article, we will cover the effectiveness of balstilimab combined with zalifrelimab in the treatment of cervical cancer. Balstilimab is an immunotherapeutic drug that does not act on the tumor directly. Instead, it helps the immune system become better at identifying and neutralizing cancer cells. Some tumors have the ability to evade T-cell detection, which gives them the liberty to grow and spread uncontrollably.
Balstilimab binds to specific receptors on T-cells , preventing cancer proteins i. As a result of this interaction, T-cells continue to recognize and kill tumor cells.
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